Completed Projects

Host biomarkers for investigating the spectrum of M. tuberculosis infection

Background:Evaluation of cytokines and chemokines that distinguish active TB, including extrapulmonary TB, from latent Mtb infection. Using archived, cryopreserved PBMC samples collected by Dr. Bruno Andrade in Salvador, Brazil, we are evaluating the performance of our candidate biomarkers in individuals with varying degrees of severity of Mtb infection and disease, including LTBI, sub-clinical TB and ATB; the latter will include both pulmonary and extrapulmonary disease. We will also assess our biomarkers in samples derived from individuals with presumptive TB (symptomatic or asymptomatic) for whom diagnostic tests were negative for TB.
Primary aims:Evaluate the performance of T cell biomarkers for diagnosing TB across the spectrum of Mtb infection in HIV-uninfected and HIV-infected individuals.
Current status: A paper describing our results was published in CID (please refer to Publications).
Principal Investigators (Consortium PIs):Jyothi Rengarajan, Ph.D., Bruno Andrade, M.D., Ph.D.