Salvador site

Salvador, Bahia

RePORT-Brazil Coordination Center

The RePORT-Brazil Coordination Center is the central hub for coordinating and facilitating research activities among the consortium members. The Coordination Center plays a pivotal role in ensuring effective communication, collaboration, and synergy among the participating research institutions. The Coordination Center also facilitates resource allocation, manages timelines, and monitors the progress of research projects.

  • Principal Investigator: Bruno de Bezerril Andrade
  • Program Manager: Mariana Araújo Pereira
  • Administrative support and Project Manager: Elze Leite

The anatomy of the site located in Salvador-BA consists of five different structures: the Gonçalo Moniz Institute (IGM)-Fiocruz, the Institute of Clinical and Translational Research (IPCT), the José Silveira Foundation (FJS), the Biorepository, and the MONSTER Initiative.

The Gonçalo Moniz Institute (IGM) is a renowned research institution located in Salvador, Brazil. As part of the Oswaldo Cruz Foundation (Fiocruz), the IGM focuses on advancing scientific knowledge and innovation in the field of biomedical research. The Investigative Medicine Unit (IMU) is an advanced laboratory within the Inflammation and Biomarkers Laboratory (LIB) of the IGM-Fiocruz.

The Institute of Clinical and Translational Research (IPCT) is a specialized environment that plays a crucial role in conducting experiments to evaluate the immunoresponse of individuals through a Luminex facility. Moreover, it plays an essential role in translating research findings into clinical practice, helping identify promising and effective strategies for disease treatment and prevention.

The biorepository plays a crucial role in scientific and medical research by providing a centralized storage facility for biological samples from RePORT-Brazil. More than 275,000 specimens have been collected and stored at the Biorepository in Salvador, Bahia; including Mycobacterium tuberculosis (Mtb) isolates, sputum, blood, urine, DNA, and plasma at baseline and during follow-up.

Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) aims to investigate diseases through molecular, epidemiological and network approaches. By using machine learning and systems biology approaches, the MONSTER Initiative contributes to improving public health outcomes. MONSTER is responsible for most of data processing and analysis for RePORT-Brazil and other RePORT networks.

IBIT, Salvador (clinical site)

Unit of the José Silveira Foundation (FJS) (http://www.fjs.org.br/), a non-profit institution, the Brazilian Tuberculosis Research Institute (IBIT) was founded in 1937, in the state of Bahia / Brazil, and accredited by the government as a TB treatment center. The doctor and Professor José Silveira, founder of IBIT, created a research program on tuberculosis that included participation in the research of primary drugs and drug schemes against tuberculosis. Currently, FJS / IBIT serves as a reference center for primary TB care and annually treats 10 to 15% of TB cases in the city of Salvador. This Institute is part of the National TB Control Program and follows all guidelines and recommendations from the Brazilian Society of Pulmonology and Tisiology, which are similar to WHO recommendations.

IBIT is located close to other FJS buildings. It has 4 rooms for clinical evaluations, two for nursing procedures, one for social support, an auditorium (76 seats), two meeting rooms, a research center, a room for food distribution, a waiting room, a clinical analysis laboratory, a mycobacteriology reference laboratory, 1 induced sputum collection room, sample collection room, spontaneous sputum collection room and IT technical support.  With a comprehensive patient support model aligned with the National Tuberculosis Control Program, IBIT provides medical assistance in the areas of pneumology, tisiology, pediatrics and general medicine clinic, in addition to nutritional care, nursing and social work. Such procedures ensure cure rates for patients with tuberculosis above 88% over the last 10 years. For the benefit of patients, IBIT also develops social support, nutritional monitoring and food supplementation, regularly distributing soy bread, soy milk and basic food baskets.

The Research and Innovation Center is a structured unit with administrative and meeting room, space for file storage, monitor research participants, holding a team of medical researchers to support data analysis, study coordinators and research nurses. The research team is qualified to carry clinical and basic research in several areas, mainly in tuberculosis. Since its creation, the Research Center has been conducting or supporting several research projects on tuberculosis, arthritic diseases and in recent years it has carried out several international collaborations, resulting in scientific publications of international relevance.

  • First participant recruited in June 2016

    Bruno Bezerril Andrade, MD PhD

  • Population: DS-TB and TB close-contacts
  • Enrolled 584 participants to date (273 TB cases and 311 close contacts)
  • Phase 2 enrollment is ongoing (2022-2027)
  • Micro Lab and Research Center: IBIT, FJS / Immuno Lab: IGM, Fiocruz-BA
  • Data analysis center: MONSTER

Research and Innovation Center, IBIT – Salvador

RePORT-Brazil PI: Bruno de Bezerril Andrade
Research center coordinator: Eduardo M. Netto
Research coordinator: Michael Rocha
Research nurse: Vanessa Nascimento, Milena Lima
Research Physician: Betânia Nogueira, Victor Porfirio

Microbiology Laboratory, IBIT – Salvador

  • Collaborator: Saulo Santos

    Collaborator Saulo Santos

  • Lab is responsible for processing all samples from the IBIT site
    • Over 270 TB patients from RePORT (Phase 1), with samples collected at Baseline, M1, M2 and end of treatment.
  • Evaluated by SMILE since 2013 (for RePORT)
  • External (SMILE, Westat, PPD) and internal (Lourenço) monitoring visits

Immunology and Molecular Biology Laboratory, IGM-FIOCRUZ Bahia

The Investigative Medicine Unit (IMU) is an advanced laboratory within the Inflammation and Biomarkers Laboratory (LIB) of the Gonçalo Moniz Institute (IGM), Oswaldo Cruz Foundation (FIOCRUZ), located in Salvador.

  • Immunology Coordinator: Alice Andrade
  • Immunology Technician: Jessica Lobo, Dayse Lira
  • Molecular Biology Technician: Flavio Santos, Yasmin Monara
  • Lab is responsible for processing all samples from the IBIT site
    • Over 580 participants from RePORT (Phase 1), with samples collected at Baseline, M1, M2 and end of treatment.
    • PBMCs and QuantiFERON, as well as plasma, urine, RNA, etc.
  • Evaluated by Duke University since June 2015
  • QuantiFERON training
  • External (Westat, PPD) monitoring visits

MONSTER Initiative at IGM FIOCRUZ – Bahia

Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) is responsible for most of data processing and analysis for RePORT-Brazil and other RePORT networks.

Principal Investigator: Bruno de Bezerril Andrade
Data Analysts: Artur Trancoso, Joao Miguez, Beatriz Duarte, Mariana Araujo Pereira, Moreno Rodrigues
Associate Researcher (TB-RICC) and data analyst: Mariana Araujo Pereira
Administrative support: Elze Leite (Project Manager)

Salvador Clinical Team
Salvador Immunology Team
Data Analysts, MONSTER Initiative